Institute for Advanced Biosciences · Grenoble
Translational Theranostics Team
Seeing, measuring and treating disease: from X-ray waves and metals to theranostic compounds.
- Translational investigations
- Medical and biological imaging
- Medical devices
- Theranostic compounds
- Elucidating disease mechanisms
- Diagnostic imaging
- Theranostics (nano)vectors
Short WaveInfra Red
X-rayFluorescence
X-ray Phase ContrastDark-field
Laser Induced BreakdownSpectroscopy
Metallomic
VirtualHistology
Single cell
Image guidedsurgery
FunctionalImaging
Boron neutroncapture
therapy
Cell TherapyMonitoring
What drives us
Three objectives, one translational continuum
From the bench to the bedside, we work where physics, chemistry and medicine meet, with clinicians in the team.
- Understand disease mechanismsTell physiology from pathology, and follow the response to treatment, notably through the role of metals in health.
- Develop imaging instruments and toolsNew instruments and contrast agents, validated for preclinical and clinical use, from 3D imaging of biopsies to optimised tumour surgery.
- Design theranostic compoundsTargeted nanovectors and drugs that combine imaging, optical or X-ray, with remote activation by neutrons, light or enzymes, to reinforce the cancer arsenal.
Research
Three groups
Metals in Medicine
Elemental imaging of cells and tissues to understand how metals shape health and disease, and to find the causes of idiopathic diseases.
ExploreX-Ray Wave Imaging for Health
Phase-contrast and dark-field X-ray imaging, from the synchrotron to the laboratory and the clinic, for 3D exploration of unlabelled tissue.
ExploreImage-guided Surgery and Neutron Capture Therapy
Fluorescent and multimodal probes to guide tumour surgery, and boron-based compounds for neutron capture therapy.
ExploreBetter together
Each group feeds the others
Molecular probes designed in one group are localised in cells and tissues by another; contrast mechanisms understood with X-ray waves guide the analysis of metals; contrast agents are tested at the scale of the whole organ. This loop is what makes the team translational.
- Metals in Medicine ↔ Image-guided Surgery and NCT: molecular probes, and sub-cellular and tissue localisation.
- Metals in Medicine ↔ X-Ray Wave Imaging: understanding of low-frequency contrast, and image analysis with artificial intelligence.
- Image-guided Surgery and NCT ↔ X-Ray Wave Imaging: in-vivo organ-level localisation, and molecular contrast agents.
In numbers
A productive, well-connected team
- 139publications since 2019
- 5patents, one of them licensed
- 14PhD theses defended
- 9PhD students in progress
- 7postdoctoral researchers hosted
- 2unique platforms: MUSITOX and Bio-LIBS
Unique instruments
Platforms open to the community
News
Latest from the team
The Translational Theranostics Team starts in January 2027
Imaging physics, elemental imaging and theranostics join forces in a single team at the Institute for Advanced Biosciences.
arXimed: bringing phase-contrast X-ray imaging to clinics
The arXimed project, supported by the SATT Linksium, takes wave-based X-ray imaging toward clinical systems for radiology.
Bio-LIBS, the first LIBS microscope in a hospital, is installed
A unique elemental microscope for biomedical samples is now running at Grenoble Alpes University Hospital.
Collaborations
Working with partners worldwide
- Monash University
- University of Canterbury
- Université libre de Bruxelles
- Politecnico di Milano
- Lund University
- Universidad de Granada
- Universität Duisburg-Essen
- Czech Academy of Sciences
- Ikerbasque
- KU Leuven
- ESRF
- Synchrotron SOLEIL
- Neutrons for Society
- CHU Grenoble Alpes
- Ablatom
- CREATIS
- Université de Lille
- Université de Strasbourg
- AP-HP
- Institut Lumière Matière
- CRNL